Version 1 of #2359

They are the same knowledge in terms of encoding knowledge about the environment, and possible transformations based on that. That knowledge can differ in reach (context independence/how fundamental it is).

Their mode of replication differ, as each new guess in genes must be neutral or positive for the vehicle. This makes genes slower, but that's IMO a quantitative difference, not a qualitative one. Pure genetic konwledge could colonize the galaxy, it'd take much longer than with memes.