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The criticism "this is replicating less" should be generalized to "this allele/information has less causal power than an alternative." That has tremendous weight.
There is a natural preference for the one with more causal power, it is naturally selected over alternatives.
However, it is not clear to me how you are "weighing" these criticisms. So maybe my weighing isn't relevant to your weighing.
Natural selection requires differential replication, not death. (Death is just an extreme form of differential replication, when compared to any allele that does replicate.)
How much time and energy do you really have for research while working? 1hr daily? 2 hours daily? 4 hours daily?
Leaving your job allows for the possibility of consistent high quality research daily.